2-Bromo-4'-hydroxyacetophenone

Names

[ Name ]:
2-Bromo-4'-hydroxyacetophenone

[Synonym ]:
4-(Bromoacetyl)phenol
PTP INHIBITOR I
4-Hydroxyphenacyl Bromide
Ethanone, 2-bromo-1-(4-hydroxyphenyl)-
Butrol 1130
p-Hydroxyphenacyl BroMide
2-Bromo-1-(4-hydroxyphenyl)ethanone
BHAP
2-Bromo-4'-Hydroxy-Acetophenone
2-Bromo-4-Hydroxyacetophenone
MFCD00072424
4-HYDROXYPHENACYL BR
2-Bromo-1-(4-hydroxyphenyl)ethanone p-Hydroxyphenacyl bromide
BUSAN1130
2-Bromo-4’-hydroxyacetophenone
BUSAN90
BROMOHYDROXYACETOPHENONE
1-(4-hydroxyphenyl)-2-bromoethanone
EINECS 219-655-0

Biological Activity

[Description]:

2-Bromo-4'-hydroxyacetophenone a PTP1B inhibitor, with a Ki of 42 μM[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

Research Areas >> Others

[Target]

Ki: 42 μM (PTP1B)[1].

[References]

[1]. Sidhu, Alban, et al. Toward Inhibitors of Protein Tyrosine Phosphatases for Cancer Treatment. Home / Current Enzyme Inhibition, Volume 4, Number 1.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
338.7±17.0 °C at 760 mmHg

[ Melting Point ]:
123-126°C

[ Molecular Formula ]:
C₈H₇BrO₂

[ Molecular Weight ]:
215.044

[ Flash Point ]:
158.6±20.9 °C

[ Exact Mass ]:
213.962936

[ PSA ]:
37.30000

[ LogP ]:
1.95

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.609

[ Storage condition ]:
-70°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AM5982000

CHEMICAL NAME :: Acetophenone, 2-bromo-4'-hydroxy-

CAS REGISTRY NUMBER :: 2491-38-5

BEILSTEIN REFERENCE NO. :: 1865388

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C8-H7-Br-O2

Safety Information

[ Hazard Codes ]:
C: Corrosive;

[ Risk Phrases ]:
22-36

[ Safety Phrases ]:
26

[ RIDADR ]:
UN 1760

[ Packaging Group ]:
III

[ HS Code ]:
2914700090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914700090

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%