CAXII-IN-1

Names

[ Name ]:
CAXII-IN-1

Biological Activity

[Description]:

CAXII-IN-1 (Compound 17) is a selective CA XII inhibitor with Ki values of 3.8 nM and 56.0 nM against hCA XII and hCA IX, respectively. CAXII-IN-1 shows antitumor activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase

[Target]

IC50: 3.8 nM (hCA XII), 56.0 nM (hCA IX)[1]

[In Vitro]

CAXII-IN-1 (Compound 17) shows cytotoxicity with IC50 values of 20±1, 4.8±0.03 and 14±2 µM against MCF-7, HeLa and A549 cells, respectively[1].

[References]

[1]. Grandāne A, et al. Development of oxathiino[6,5-b]pyridine 2,2-dioxide derivatives as selective inhibitors of tumor-related carbonic anhydrases IX and XII. Eur J Med Chem. 2020 Aug 15;200:112300.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₇Cl₂NO₃S

[ Molecular Weight ]:
328.17

Related Compounds

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