Lenperone Hydrochloride

Names

[ Name ]:
Lenperone Hydrochloride

[Synonym ]:
ahr-2277

Biological Activity

[Description]:

Lenperone hydrochloride (AHR 2277) is an antipsychotic compound and a dopamine antagonist. Lenperone hydrochloride reduces gastroesophageal sphincter pressure of healthy dogs. Lenperone hydrochloride can be used for neurological disease research[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

[In Vivo]

Lenperone hydrochloride (0.16 和 0.44 mg/kg；肌内注射；一次) 降低健康犬的平均值胃食管括约肌压力 (GESP)[1]。 Lenperone hydrochloride (0.5，1.0 和 2.0 mg/kg；皮下注射) 在脑损伤大鼠中显示抗精神疾病的作用，诱导剂量依赖的镇静状态并减少双侧间质核、终纹[2]。 Animal Model: Healthy adult dogs[1] Dosage: 0.16 and 0.44 mg/kg Administration: Intramuscular injection; 0.16 and 0.44 mg/kg, once Result: Effectively decreased gastroesophageal sphincter pressure (GESP) of dogs.

[References]

[1]. Johnson SE, et al. Effect of lenperone hydrochloride on gastroesophageal sphincter pressure in healthy dogs. Can J Vet Res. 1989 Apr;53(2):248-50.

[2]. Costall B, Naylor RJ. Mesolimbic involvement with behavioural effects indicating antipsychotic activity. Eur J Pharmacol. 1974 Jun;27(1):46-58.

Chemical & Physical Properties

[ Density]:
1.186g/cm3

[ Boiling Point ]:
507.9ºC at 760mmHg

[ Molecular Formula ]:
C₂₂H₂₄ClF₂NO₂

[ Molecular Weight ]:
407.88100

[ Flash Point ]:
261ºC

[ Exact Mass ]:
407.14600

[ PSA ]:
37.38000

[ LogP ]:
5.26250

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EU2456000

CHEMICAL NAME :: Butyrophenone, 4-(4-(p-fluorobenzoyl)piperidino)-4'-fluoro-, hydrochloride

CAS REGISTRY NUMBER :: 24677-86-9

LAST UPDATED :: 198812

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C22-H23-F2-N-O2.Cl-H

MOLECULAR WEIGHT :: 407.92

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 135 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 13,1,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 13,1,1970

Related Compounds

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