Muscarine iodide

Names

[ Name ]:
Muscarine iodide

[Synonym ]:
2-Iodomelatonin

Biological Activity

[Description]:

Muscarine ((+)-Muscarine) iodide is a toxin that can stimulate the parasympathetic nervous system. Muscarine iodide is a prototype muscarinic acetylcholine receptor agonist[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR

Signaling Pathways >> GPCR/G Protein >> mAChR

Research Areas >> Neurological Disease

[In Vitro]

Muscarine iodide administration (100 µM) induces an intracellular calcium signal amplitude similar to the one triggered by 10 µM ACh[1]. Muscarine iodide (1-30 μM) produces a dose-dependent hyperpolarization in a sub-population of the NRM cells that contain 5-hydroxytryptamine (5-HT) on the NRM neurons[2].

[References]

[1]. Beatrice Mihaela Radu, et al. All muscarinic acetylcholine receptors (M 1-M 5) are expressed in murine brain microvascular endothelium. Sci Rep. 2017 Jul 11;7(1):5083.

[2]. Z Z Pan, et al. Muscarine hyperpolarizes a subpopulation of neurons by activating an M2 muscarinic receptor in rat nucleus raphe magnus in vitro. J Neurosci. 1994 Mar;14(3 Pt 1):1332-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₉H₂₀INO₂

[ Molecular Weight ]:
301.16500

[ Exact Mass ]:
301.05400

[ PSA ]:
29.46000

Muscarine iodide

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds