Antitrypanosomal agent 4

Names

[ CAS No. ]:
2456427-48-6

[ Name ]:
Antitrypanosomal agent 4

Biological Activity

[Description]:

Antitrypanosomal agent 4 (compound 19) is a potent and blood-brain barrier permeable antitrypanosomal agent. Antitrypanosomal agent 4 has good activity against Trypanosoma cruzi (T. cruzi) and Trypanosoma brucei brucei (T. b. brucei) with IC50s of 1.2 μM and 70 nM, respectively[1].

[Related Catalog]:

Research Areas >> Infection

[Target]

IC50: 1.2 μM (T. cruzi), 70 nM (T. b. brucei)[1]


[References]

[1]. Fersing C, Boudot C, Castera-Ducros C, et al. 8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi. Eur J Med Chem. 2020;202:112558.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H14ClN3O5S

[ Molecular Weight ]:
419.84

Related Compounds

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