Antitrypanosomal agent 7

Names

[ Name ]:
Antitrypanosomal agent 7

Biological Activity

[Description]:

Antitrypanosomal agent 7 (compound 18c) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 7 is > 2-fold more potent against Trypanosoma brucei (T. brucei) than Nifurtimox, with an IC50 value of 0.71 μM. Antitrypanosomal agent 7 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA[1].

[Related Catalog]:

Research Areas >> Infection

[Target]

IC50: 0.71 μM (T. brucei)[1]

[References]

[1]. Popov AB,et al. DNA/RNA binding and in vitro ADME profiling of novel imidazoline-substituted 2-arylbenzimidazoles. Eur J Med Chem. 2020 Dec 1;207:112802.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₃₁Cl₂N₅O₂

[ Molecular Weight ]:
480.43

Related Compounds

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