Antitrypanosomal agent 9

Names

[ Name ]:
Antitrypanosomal agent 9

[Synonym ]:
Methanone, [4-[(4-ethoxyphenoxy)methyl]phenyl](3-methyl-1-piperidinyl)-
{4-[(4-Ethoxyphenoxy)methyl]phenyl}(3-methyl-1-piperidinyl)methanone

Biological Activity

[Description]:

Antitrypanosomal agent 9 (compound 1) is a potent antitrypanosomal agent. Antitrypanosomal agent 9 shows inhibitory activity against T. b. brucei, with an IC50 of 1.15 μM. Antitrypanosomal agent 9 can be used for human African trypanosomiasis (HAT) research[1].

[Related Catalog]:

Research Areas >> Infection

[In Vitro]

Antitrypanosomal agent 9 (compound 1) shows inhibitory activity against T. b. rhodesiense, T. cruzi, L. donovani, and P. falciparum, with IC50 values of 0.985 ± 0.076, 107 ± 34.5, 35.7 ± 6.22, and 22.3 ± 1.06 μM, respectively[1]. Antitrypanosomal agent 9 shows cytotoxicity in L6 cells, with an IC50 of 186 ± 94.2 μM[1].

[References]

[1]. Manos-Turvey Alexandra, et al. Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents. Med Chem Commun. 2015, 6(3), 403–406.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
521.5±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₇NO₃

[ Molecular Weight ]:
353.45

[ Flash Point ]:
269.2±25.9 °C

[ Exact Mass ]:
353.199097

[ LogP ]:
4.00

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.560

Related Compounds

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