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Sphingosine (d14:1)

Names

[ CAS No. ]:
24558-60-9

[ Name ]:
Sphingosine (d14:1)

[Synonym ]:
Tetradephing-4-enine
D-erythro-C14-sphingosine
(E)-D-erythro-2-AMino-4-tetradecene-1,3-diol
C14-Sphingosine
(2S,3R,E)-2-Amino-4-tetradecene-1,3-diol
(2S,3R)-amino-tetradeca-4-ene-1,3-diol

Biological Activity

[Description]:

Sphingosine (d14:1) (Tetradecasphing-4-enine), a sphingolipid, is a potent Protein kinase C (PKC) inhibitor. Sphingosine (d14:1) prevents its interaction with sn-1,2-diacylglycerol (DAG)/Phorbol esters[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC
Research Areas >> Cancer
Signaling Pathways >> TGF-beta/Smad >> PKC

[Target]

PKC


[References]

[1]. Y A Hannun, et al. Regulation of protein kinase C by sphingosine and lysosphingolipids. Clin Chim Acta. 1989 Dec 15;185(3):333-45.

Chemical & Physical Properties

[ Density]:
0.963 g/cm3

[ Boiling Point ]:
392.552ºC at 760 mmHg

[ Molecular Formula ]:
C14H29NO2

[ Molecular Weight ]:
243.38600

[ Flash Point ]:
191.209ºC

[ Exact Mass ]:
243.22000

[ PSA ]:
66.48000

[ LogP ]:
3.06410

Related Compounds