ALV1

Names

[ Name ]:
ALV1

Biological Activity

[Description]:

ALV1 is a potent Ikaros and Helios degrader. ALV1 potently reduces the protein abundance of IKZF1-4, CK1α (casein kinase 1α, CSNK1A1) and ribosomal protein RPL4. ALV1 shows similar degradation activity towards IKZF1/2/3. ALV1 induced Helios/CRBN dimerization. ALV1 promoted IL-2 secretion to a great extent[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Cell Cycle/DNA Damage >> Casein Kinase

Signaling Pathways >> Stem Cell/Wnt >> Casein Kinase

Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[Target]

CK1α

[References]

[1]. Wang ES, et al. Acute pharmacological degradation of Helios destabilizes regulatory T cells. Nat Chem Biol. 2021 Jun;17(6):711-717.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₃ClN₄O₅

[ Molecular Weight ]:
494.93

Related Compounds

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