TP0586532

Names

[ Name ]:
TP0586532

Biological Activity

[Description]:

TP0586532 is a non-hydroxamate LpxC inhibitor (IC50=0.101 μM). TP0586532 as a compound with a low cardiovascular risk that is effective against K. pneumoniae, including resistant strains[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: 0.101 μM (non-hydroxamate LpxC)[1]

[In Vitro]

TP0586532 as a compound with a low cardiovascular risk that is effective against K. pneumoniae, including resistant strains[1].

[References]

[1]. Ushiyama F, et al. Lead optimization of 2-hydroxymethyl imidazoles as non-hydroxamate LpxC inhibitors: Discovery of TP0586532. Bioorg Med Chem. 2021;30:115964.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₈N₄O₄

[ Molecular Weight ]:
460.52

Related Compounds

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