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APC 366 TFA

Names

[ CAS No. ]:
2421110-28-1

[ Name ]:
APC 366 TFA

Biological Activity

[Description]:

APC 366 (TFA) is an irreversible mast cell tryptase inhibitor. APC 366 (TFA) can be used for the research of allergic diseases[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[Target]

mast cell tryptase[1]


[In Vivo]

APC 366 (TFA) (5 mg/kg/0.1 ml; s.c.) reduces the eosinophil recruitment induced by PAR-2 activating peptide[1]. Animal Model: Male BALB/c mice (18–25 g)[1] Dosage: 5 mg/kg/0.1 ml Administration: S.c. Result: Reduced the eosinophil recruitment induced by PAR-2 activating peptide.

[References]

[1]. Matos NA, et al. Mast cell tryptase induces eosinophil recruitment in the pleural cavity of mice via proteinase-activated receptor 2. Inflammation. 2013;36(6):1260-1267.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H29F3N6O6

[ Molecular Weight ]:
554.52

Related Compounds