Zorevunersen

Names

[ Name ]:
Zorevunersen

Biological Activity

[Description]:

Zorevunersen (STK-001) is an antisense oligonucleotide that is intended to increase the level of productive SCN1A mRNA and consequently increase the expression of the sodium channel Nav1.1 protein. Zorevunersen is used for the study of Dravet syndrome.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Research Areas >> Others

[Target]

Nav1.1

[References]

[1]. Wengert ER, Wagley PK, Strohm SM, et al. Targeted Augmentation of Nuclear Gene Output (TANGO) of Scn1a rescues parvalbumin interneuron excitability and reduces seizures in a mouse model of Dravet Syndrome. Brain Res. 2022;1775:147743.

[2]. Bialer M, Johannessen SI, Koepp MJ, et al. Progress report on new antiepileptic drugs: A summary of the Sixteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVI): II. Drugs in more advanced clinical development. Epilepsia. 2022;63(11):2883-2910.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀₄H₂₆₃N₆₃O₁₁₄P₂₀S₂₀

[ Molecular Weight ]:
6682.39

Related Compounds

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