Gly-Cyclopropane-Exatecan

Names

[ Name ]:
Gly-Cyclopropane-Exatecan

Biological Activity

[Description]:

Gly-Cyclopropane-Exatecan involves in the synthesis of anti-B7-H4 ADC, containing Exatecan (HY-13631), a DNA Topoisomerase I inhibitor. Gly-Cyclopropane-Exatecan participated in the formation of the ADC hu2F7-Exatecan (compound 34), which showed antitumor activity in vivo and in vitro[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin

[Target]

Topoisomerase I

[References]

[1]. Hua Haiqing, et al. Anti-b7-h4 antibody-drug conjugate and medicinal use thereof: World Intellectual Property Organization, WO2020244657. 2020-12-10.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₂H₃₄FN₅O₇

[ Molecular Weight ]:
619.64

Related Compounds

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