Antibacterial agent 83

Names

[ Name ]:
Antibacterial agent 83

Biological Activity

[Description]:

Antibacterial agent 83 (compound 17h) displays potent antibacterial activity against various vancomycin-resistant Enterococcus faecalis (VRE) and methicillin-resistant Staphylococcus aureus (MRSA). Antibacterial agent 83 can significantly reduce the biofilm formation of MRSA and exhibited promising selectivity. Antibacterial agent 83 is metabolically stable in human liver microsomes[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Antibacterial agent 83 (compound 17h) 对 Newmana、USA300b、Mu50 均有抗菌作用，MIC 均为0.25 μg/mL[1]。 Antibacterial agent 83 在大鼠、小鼠和犬肝微粒体中稳定性较差[1]。

[References]

[1]. Huan X, et al. Design, synthesis, and biological evaluations of substituted pyrazoles as pyrrolomycin analogues against staphylococcal biofilm. Eur J Med Chem. 2022 Jun 5;236:114309.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₅Cl₂N₃O₂

[ Molecular Weight ]:
282.08

Related Compounds

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