Py-MPB-amino-C3-PBD

Names

[ Name ]:
Py-MPB-amino-C3-PBD

Biological Activity

[Description]:

Py-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Py-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

Pyrrolobenzodiazepines

[In Vitro]

Py-MPB-amino-C3-PBD (compound 73) shows cytotoxicity with IC50s of 301, 144.1 and 37.5 nM for U138-MG, A431, and REH cells, respectively. Py-MPB-amino-C3-PBD possesses potent anti-bacterial effects against the gram negative strain E. coli K12, with potency of 2 pg/mL determined[1].

[References]

[1]. David Edwin Thurston, et al. Polycyclic amides as cytotoxic agents. WO2020049286A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₁H₄₄N₈O₆

[ Molecular Weight ]:
744.84

Py-MPB-amino-C3-PBD

Names

Biological Activity

Chemical & Physical Properties

Related Compounds