Aniline-MPB-amino-C3-PBD

Names

[ Name ]:
Aniline-MPB-amino-C3-PBD

Biological Activity

[Description]:

Aniline-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Aniline-MPB-amino-C3-PBD is a sequence-selective DNA minor-groove binding agent. Aniline-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

Pyrrolobenzodiazepines

[In Vitro]

Aniline-MPB-amino-C3-PBD (compound 16) shows cytotoxicity with IC50s of 77, 72, 79, 184.3, 61.5, and 145.6 nM for SW48, LIM1215, SW620, U138-MG, A431, and REH cells, respectively. Aniline-MPB-amino-C3-PBD effectively stabilises DNA with a degree of sequence-specificity. Aniline-MPB-amino-C3-PBD possesses potent anti-bacterial effects against the gram negative strain E. coli K12 with potency of 2 pg/mL determined[1].

[References]

[1]. David Edwin Thurston, et al. Polycyclic amides as cytotoxic agents. WO2020049286A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₂H₄₆N₈O₆

[ Molecular Weight ]:
758.86

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.