IACS-15414

Names

[ CAS No. ]:
2411321-29-2

[ Name ]:
IACS-15414

Biological Activity

[Description]:

IACS-15414 is a potent and orally bioavailable SHP2 inhibitor with an IC50 value of 122 nM.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

[References]

[1]. Czako B, et al. Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor. J Med Chem. 2021 Oct 28;64(20):15141-15169.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₄Cl₂N₄O₂

[ Molecular Weight ]:
423.34

Related Compounds

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