3alpha,21-dihydroxy-5alpha-pregnane-11,20-dione 21-acetate

Names

[ Name ]:
3alpha,21-dihydroxy-5alpha-pregnane-11,20-dione 21-acetate

[Synonym ]:
2-phenoxyethyl 4-(2,3-dimethoxyphenyl)-7-(4-methoxyphenyl)-2-methyl-5-oxo-1,4,6,7,8-pentahydroquinoline-3-carboxylate
2-phenoxyethyl 4-(2,3-dimethoxyphenyl)-7-(4-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
endo-Bicyclo<3.3.1>nonan-3-ol
exo-Bicyclo<3.3.1>nonanol-3
exo-Bicyclo<3.3.1>nonan-3-ol

Biological Activity

[Description]:

Alphadolone acetate (Alfadolone acetate) is a steroid anaesthetic, with antinociception[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vivo]

Alphadolone acetate (anaesthetized with a 3:1 mixture of Alphaxalone and Alphadolone acetate; i.m.) blocks the oestrogen-stimulated luteinizing hormone (LH) surge and impairs pulsatile secretion in female rats, when combined with alphaxalonet[2]. Alphadolone acetate (14 mL/kg; i.p.; single dosage) decreases serum concentrations of LH in castrated rats[3]. Animal Model: Inbred Wistar-derived colony female rats (intramuscularly injected with 20 µg/100g oestradiol benzoate)[2] Dosage: Anaesthetized with a 3 :1 mixture of Alphaxalone and Alphadolone acetate Administration: i.m. Result: Blocked the oestrogen-stimulated LH surge and impairs pulsatile secretion. Animal Model: Male Sprague-Dawley rats (orchidectomized; aged 90-120 days and weighing 300-350 g)[3] Dosage: 14 mL/kg Administration: i.p.; single dosage Result: Decreased serum concentrations of LH.

Chemical & Physical Properties

[ Density]:
1.164g/cm3

[ Boiling Point ]:
523.6ºC at 760mmHg

[ Molecular Formula ]:
C₂₃H₃₄O₅

[ Molecular Weight ]:
390.51300

[ Flash Point ]:
175.1ºC

[ Exact Mass ]:
390.24100

[ PSA ]:
80.67000

[ LogP ]:
3.31740

[ Vapour Pressure ]:
3.75E-13mmHg at 25°C

[ Index of Refraction ]:
1.53

Related Compounds

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