1-Methylpyrene

Names

[ Name ]:
1-Methylpyrene

[Synonym ]:
Pyrene,3-methyl
1-methyl-pyren
1-Methylpyrene
4-05-00-02475 (Beilstein Handbook Reference)
L666 B6 2AB PJ G1
3-Methylpyrene
Pyrene, 1-methyl-
MFCD00014329
1-methyl pyrene
Methylpyrene
PYRENE,1-METHYL
1-methyl-pyrene
EINECS 219-178-8
L666 B6 1A PJ G1

Biological Activity

[Description]:

1-Methylpyrene is a fluorescent probe and is also a carcinogen in rodents (λex = 346 nm; λem = 378 nm)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Monien BH, et al. Time course of hepatic 1-methylpyrene DNA adducts in rats determined by isotope dilution LC-MS/MS and 32P-postlabeling. Chem Res Toxicol. 2008 Oct;21(10):2017-25.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
387.4±9.0 °C at 760 mmHg

[ Melting Point ]:
72-74 °C(lit.)

[ Molecular Formula ]:
C₁₇H₁₂

[ Molecular Weight ]:
216.277

[ Flash Point ]:
178.9±12.8 °C

[ Exact Mass ]:
216.093903

[ LogP ]:
5.63

[ Vapour Pressure ]:
0.0±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.816

[ Water Solubility ]:
DMSO: soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UR2460000

CHEMICAL NAME :: Pyrene, 1-methyl-

CAS REGISTRY NUMBER :: 2381-21-7

BEILSTEIN REFERENCE NO. :: 1868500

LAST UPDATED :: 199710

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C17-H12

MOLECULAR WEIGHT :: 216.29

WISWESSER LINE NOTATION :: L666 B6 2AB PJ G1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 42 mg/kg/3D-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 180 umol/L/2H

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 39,4152,1979

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UR2460000

[ HS Code ]:
2902909090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2902909090

[ Summary ]:
2902909090 other aromatic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

Articles

Nitroanilines as quenchers of pyrene fluorescence.

ChemPhysChem 13(18) , 4195-201, (2012)

The quenching of pyrene and 1-methylpyrene fluorescence by nitroanilines (NAs), such as 2-, 3-, and 4-nitroaniline (2-NA, 3-NA, and 4-NA, respectively), 4-methyl-3-nitroaniline (4-M-3-NA), 2-methyl-4-...

Polycyclic aromatic hydrocarbons and the diffuse interstellar bands: a survey.

Astrophys. J. 526 Pt 1 , 265-73, (1999)

We discuss the proposal relating the origin of some of the diffuse interstellar bands (DIBs) to neutral and ionized polycyclic aromatic hydrocarbons (PAHs) present in interstellar clouds. Laboratory s...

1-Sulfooxymethylpyrene is an electrophilic mutagen and ultimate carcinogen of 1-methyl- and 1-hydroxymethylpyrene.

Biochem. Biophys. Res. Commun. 228(1) , 105-9, (1996)

1-Hydroxymethylpyrene and 1-sulfooxymethylpyrene were tested for complete carcinogenic activity by repeated s.c. injection in groups of 12 female Sprague-Dawley rats, respectively. A dose of 0.2 mumol...