Pyrene
Names
[ CAS No. ]:
129-00-0
[ Name ]:
Pyrene
[Synonym ]:
Pyrene
Pyren
Benzo[def]phenanthrene
MFCD00004136
EINECS 204-927-3
Biological Activity
[Description]:
[Related Catalog]:
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
404.0±0.0 °C at 760 mmHg
[ Melting Point ]:
145-148ºC
[ Molecular Formula ]:
C16H10
[ Molecular Weight ]:
202.251
[ Flash Point ]:
168.8±12.8 °C
[ Exact Mass ]:
202.078247
[ LogP ]:
5.17
[ Vapour Pressure ]:
0.0±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.852
[ Storage condition ]:
APPROX 4°C
[ Water Solubility ]:
almost insoluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UR2450000
- CHEMICAL NAME :
- Pyrene
- CAS REGISTRY NUMBER :
- 129-00-0
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 52
- MOLECULAR FORMULA :
- C16-H10
- MOLECULAR WEIGHT :
- 202.26
- WISWESSER LINE NOTATION :
- L666 B6 2AB PJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2700 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - conjunctive irritation Behavioral - excitement Behavioral - muscle contraction or spasticity
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 170 mg/m3
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - conjunctive irritation Behavioral - excitement Behavioral - muscle contraction or spasticity
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 800 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - conjunctive irritation Behavioral - excitement Behavioral - muscle contraction or spasticity
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 514 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 12150 mg/kg/45D-I
- TOXIC EFFECTS :
- Behavioral - muscle contraction or spasticity Blood - normocytic anemia Blood - changes in erythrocyte (RBC) count
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 10 gm/kg/3W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 10 mg/L
- REFERENCE :
- ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year: (103),64,1985 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 32,431,1983 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 32,431,1983 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** U.S. STANDARDS AND REGULATIONS *** OSHA PEL (Gen Indu):8H TWA 0.2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T1328 No. of Facilities: 11 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 32 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T1328 No. of Facilities: 560 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 9387 (estimated)
Safety Information
[ Symbol ]:
GHS08, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H341-H372-H410
[ Precautionary Statements ]:
P201-P273-P308 + P313-P391-P501
[ Target Organs ]:
Blood
[ Personal Protective Equipment ]:
Eyeshields;Gloves
[ Hazard Codes ]:
T+:Verytoxic;N:Dangerous for the environment;
[ Risk Phrases ]:
R26;R36/37/38;R50/53
[ Safety Phrases ]:
S22-S28-S36/37-S45-S60-S61
[ RIDADR ]:
UN 3077
[ WGK Germany ]:
2
[ RTECS ]:
UR2450000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
[ HS Code ]:
2902909090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2902909090
[ Summary ]:
2902909090 other aromatic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%
Articles
Regul Toxicol Pharmacol 70 Suppl 2 , S131-42, (2014)
Four versions of esterified propoxylated glycerols (EPGs) were evaluated for potential genotoxicity using a range of in vitro and in vivo assays. H-EPG-05 HR/SO 9:1, H-EPG-05 soyate, and H-EPG-14 soya...
Electrochemical polymerization of pyrene derivatives on functionalized carbon nanotubes for pseudocapacitive electrodes.Nat. Commun. 6 , 7040, (2015)
Electrochemical energy-storage devices have the potential to be clean and efficient, but their current cost and performance limit their use in numerous transportation and stationary applications. Many...
High-Sensitivity Surface-Enhanced Raman Scattering (SERS) Substrate Based on a Gold Colloid Solution with a pH Change for Detection of Trace-Level Polycyclic Aromatic Hydrocarbons in Aqueous Solution.Appl. Spectrosc. 69 , 574-9, (2015)
In this study, a gold colloid solution whose parameters were optimized, and without any surfactants, was developed as a surface-enhanced Raman scattering (SERS) substrate for the detection of trace-le...