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DC-TEADin02

Names

[ CAS No. ]:
2380228-45-3

[ Name ]:
DC-TEADin02

Biological Activity

[Description]:

DC-TEADin02 is a potent TEAD autopalmitoylation inhibitor. DC-TEADin02 has TEAD autopalmitoylation inhibitory with the IC50 value of 197 nM. DC-TEADin02 can be used for the research of development, regeneration and tissue homeostasis[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Stem Cell/Wnt >> YAP

[In Vitro]

DC-TEADin02 具有 TEAD 自棕榈酰化抑制作用，IC50 值为 197 nM[1]。 DC-TEADin02 (0-25 μM) 抑制 TEAD 转录活性，导致 YAP 相关下游基因表达下调[1]。

[References]

[1]. Wenchao Lu, et al. Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors. Eur J Med Chem. 2019 Dec 15;184:111767.  

Chemical & Physical Properties

[ Molecular Formula ]:
C19H17NO2S

[ Molecular Weight ]:
323.41

Related Compounds