2380228-45-3

2380228-45-3 structure

Name: DC-TEADin02
Chemical Name: DC-TEADin02
CAS Number: 2380228-45-3
Molecular Formula: C₁₉H₁₇NO₂S
Molecular Weight: 323.41
Catalog: Signaling Pathways Stem Cell/Wnt YAP
Create Date: 2023-02-05 14:07:29
Modify Date: 2024-04-13 18:35:30
DC-TEADin02 is a potent TEAD autopalmitoylation inhibitor. DC-TEADin02 has TEAD autopalmitoylation inhibitory with the IC50 value of 197 nM. DC-TEADin02 can be used for the research of development, regeneration and tissue homeostasis[1].

Name	DC-TEADin02

Description	DC-TEADin02 is a potent TEAD autopalmitoylation inhibitor. DC-TEADin02 has TEAD autopalmitoylation inhibitory with the IC50 value of 197 nM. DC-TEADin02 can be used for the research of development, regeneration and tissue homeostasis[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> YAP
In Vitro	DC-TEADin02 具有 TEAD 自棕榈酰化抑制作用，IC50 值为 197 nM[1]。 DC-TEADin02 (0-25 μM) 抑制 TEAD 转录活性，导致 YAP 相关下游基因表达下调[1]。
References	[1]. Wenchao Lu, et al. Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors. Eur J Med Chem. 2019 Dec 15;184:111767.

Molecular Formula	C₁₉H₁₇NO₂S
Molecular Weight	323.41