DC-TEADin1072
Names
[ CAS No. ]:
1574602-93-9
[ Name ]:
DC-TEADin1072
Biological Activity
[Description]:
DC-TEADin1072 is a novel TEAD1/3 covalent inhibitor with biochemical IC50 values of 0.61 and 0.58 uM against TEAD1 and TEAD3, respectively.TEADin1072 selectively inhibited TEAD1 and TEAD3 palmitoylation while sparing TEAD2 and TEAD4.TEADin1072 demonstrated selective engagement with Cys371 of TEAD3 and Cys359 of TEAD1.
[References]
1. Tian Lu, et al. Acta Pharm Sin B. 2021 Oct;11(10):3206-3219.
Chemical & Physical Properties
[ Molecular Formula ]:
C16H21NO2
[ Molecular Weight ]:
259.349