LY3154885

Names

[ Name ]:
LY3154885

Biological Activity

[Description]:

LY3154885 is an orally active dopamine D1 receptor positive allosteric modulator (PAM). LY3154885 has an improved drug-drug interactions (DDI) risk profile[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

[References]

[1]. Junliang Hao, et al. Synthesis and Preclinical Characterization of LY3154885, a Human Dopamine D1 Receptor Positive Allosteric Modulator with an Improved Nonclinical Drug-Drug Interaction Risk Profile. J Med Chem. 2022 Mar 10;65(5):3786-3797.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₃Cl₂N₃O₂

[ Molecular Weight ]:
444.35

Related Compounds

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