HSD1590
Names
[ CAS No. ]:
2379279-96-4
[ Name ]:
HSD1590
Biological Activity
[Description]:
HSD1590 is potent ROCK inhibitor, with IC50s of 1.22 and 0.51 nM for ROCK1 and ROCK2, respectively. HSD1590 exhibits single digit nanomolar binding to ROCK (Kds<2 nM). HSD1590 displays low cytotoxicity[1].
[Related Catalog]:
[Target]
ROCK1:1.22 nM (IC50)
ROCK2:0.51 nM (IC50)
[In Vitro]
HSD1590 (0.5-1 µM; 24 hours) exhibits an impressive attenuation in migration[1]. HSD1590 (0.5-10 µM; 12-24 horus) shows that the excellent migration inhibition observed is not due to cell death, but inhibition of live cell migration[1]. Cell Viability Assay[1] Cell Line: MDA-MB-23 cells Concentration: 0.5-10 µM Incubation Time: 12-24 hours Result: Exhibited approximately 80% viability at 12 hours and yielded an overall viability of 63% at 24 h.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C20H18BN3O3
[ Molecular Weight ]:
359.19