SMO-IN-3

Names

[ CAS No. ]:
2376914-71-3

[ Name ]:
SMO-IN-3

Biological Activity

[Description]:

SMO-IN-3 (compound 12a) is a potent smoothened (SMO) inhibitor with an IC50 value of 34.09 nM for hedgehog (Hh) signaling pathway. SMO-IN-3 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> Smo
Research Areas >> Cancer
Signaling Pathways >> Stem Cell/Wnt >> Hedgehog

[Target]

IC50: 34.09 nM (Hh)[1]


[In Vitro]

SMO-IN-3 (compound 12a) has antiproliferative activity against human medulloblastoma cell line Daoy with an IC50 of 0.48 μM[1].

[References]

[1]. Ji D, et al. Design, synthesis and biological evaluation of anthranilamide derivatives as potent SMO inhibitors. Bioorg Med Chem. 2020 Mar 15;28(6):115354.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H25F4N3O2

[ Molecular Weight ]:
499.50

Related Compounds

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