2376914-71-3

2376914-71-3 structure

Name: SMO-IN-3
Chemical Name: SMO-IN-3
CAS Number: 2376914-71-3
Molecular Formula: C₂₇H₂₅F₄N₃O₂
Molecular Weight: 499.50
Catalog: Signaling Pathways Stem Cell/Wnt Hedgehog
Create Date: 2022-08-31 18:30:24
Modify Date: 2025-08-25 18:31:27
SMO-IN-3 (compound 12a) is a potent smoothened (SMO) inhibitor with an IC50 value of 34.09 nM for hedgehog (Hh) signaling pathway. SMO-IN-3 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity[1].

Name	SMO-IN-3

Description	SMO-IN-3 (compound 12a) is a potent smoothened (SMO) inhibitor with an IC50 value of 34.09 nM for hedgehog (Hh) signaling pathway. SMO-IN-3 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Smo Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> Hedgehog
Target	IC50: 34.09 nM (Hh)[1]
In Vitro	SMO-IN-3 (compound 12a) has antiproliferative activity against human medulloblastoma cell line Daoy with an IC50 of 0.48 μM[1].
References	[1]. Ji D, et al. Design, synthesis and biological evaluation of anthranilamide derivatives as potent SMO inhibitors. Bioorg Med Chem. 2020 Mar 15;28(6):115354.

Molecular Formula	C₂₇H₂₅F₄N₃O₂
Molecular Weight	499.50