PROTAC IRAK4 degrader-3

Names

[ CAS No. ]:
2374122-43-5

[ Name ]:
PROTAC IRAK4 degrader-3

Biological Activity

[Description]:

PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> IRAK
Research Areas >> Inflammation/Immunology
Signaling Pathways >> PROTAC >> PROTAC
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK

[Target]

IRAK4


[In Vitro]

PROTAC IRAK4 degrader-3 (0.01~10 μM; 2 hours; PBMCs) mediated degradation is occurring in a proteasome dependent manner[1]. PROTAC IRAK4 degrader-3 (0.01~100 μM; 18 hours; PBMCs) is capable of completely blocking IL-6 secretion[1]. Western Blot Analysis[1] Cell Line: PBMCs Concentration: 0.01~10 μM Incubation Time: 2 hours Result: IRAK4 PROTAC-mediated degradation was occurring in a proteasome dependent manner.

[References]

[1]. Nunes J, et al. Targeting IRAK4 for Degradation with PROTACs. ACS Med Chem Lett. 2019;10(7):1081-1085. Published 2019 Jun 14.

Chemical & Physical Properties

[ Molecular Formula ]:
C57H68FN11O8S

[ Molecular Weight ]:
1086.28

[ Storage condition ]:
2-8°C

Related Compounds