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PROTAC IRAK4 degrader-1

Names

[ CAS No. ]:
2360533-90-8

[ Name ]:
PROTAC IRAK4 degrader-1

Biological Activity

[Description]:

PROTAC IRAK4 degrader-1 is a PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1 Compound I-210, makes <20%, >20-50%, and >50% IRAK4 degradation at 0.01, 0.1, and 1 μM in OCI-LY-10 cells, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> IRAK
Signaling Pathways >> PROTAC >> PROTAC
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK

[Target]

IRAK4

Cereblon


[References]

[1]. Nello Mainolfi, et al. Irak degraders and uses thereof. US20190192668A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C44H39F3N12O7

[ Molecular Weight ]:
904.85

[ Storage condition ]:
-20°C

Related Compounds