5-Fluoro-2-nitroaniline

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
295.5±20.0 °C at 760 mmHg

[ Molecular Formula ]:
C₆H₅FN₂O₂

[ Molecular Weight ]:
156.115

[ Flash Point ]:
132.5±21.8 °C

[ Exact Mass ]:
156.033508

[ PSA ]:
71.84000

[ LogP ]:
2.08

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.603

Click to get detail MSDS

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301 + H311 + H331-H373-H412

[ Precautionary Statements ]:
P261-P273-P280-P301 + P310-P311

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
23/24/25-33-52/53

[ Safety Phrases ]:
28-36/37-45-61

[ RIDADR ]:
UN 2811 6.1 / PGIII

[ HS Code ]:
2921420090

Click to get detail synthetic route

Precursor

DownStream

[ HS Code ]: 2921420090

[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Toward hypoxia-selective DNA-alkylating agents built by grafting nitrogen mustards onto the bioreductively activated, hypoxia-selective DNA-oxidizing agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).

J. Org. Chem. 79(16) , 7520-31, (2014)

Tirapazamine (3-amino-1,2,4-benzotriazine 1,4-dioxide) is a heterocyclic di-N-oxide that undergoes enzymatic deoxygenation selectively in the oxygen-poor (hypoxic) cells found in solid tumors to gener...

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