2’-β-C-Methyl-5-fluorouridine

Names

[ Name ]:
2’-β-C-Methyl-5-fluorouridine

[Synonym ]:
5-Fluoro-2'-C-methyluridine
Uridine, 5-fluoro-2'-C-methyl-

Biological Activity

[Description]:

2’-β-C-methyl-5-fluorouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Molecular Formula ]:
C₁₀H₁₃FN₂O₆

[ Molecular Weight ]:
276.22

[ Exact Mass ]:
276.075775

[ LogP ]:
-0.55

[ Index of Refraction ]:
1.626