8-Bromo-AMP

Names

[ Name ]:
8-Bromo-AMP

[Synonym ]:
8-Bromoadenosine 5'-phosphate
8-Bromoadenosine 5'-monophosphate
Adenosine,8-bromo-,5'-(dihydrogen phosphate) (8CI)
8-Bromo-5'-AMP
5'-Adenylic acid,8-bromo
8-Bromoadenosine 5'-(dihydrogen phosphate)
8-Bromo-AMP
8-Bromoadenylic acid

Biological Activity

[Description]:

8-Bromo-AMP (8-Bromoadenosine 5'-monophosphate) is a membrane permeable cAMP analogue. 8-Bromo-AMP can improve the ability of the heart to recover from ischemia and reperfusion by increasing the levels of ATP, ADP, and total adenine nucleotides[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. Jiang J, et, al. Evidences for involvement of endogenous cAMP in Arabidopsis defense responses to Verticillium toxins. Cell Res. 2005 Aug;15(8):585-92.

[2]. Nakai T, et, al. Effects of adenine nucleotide analogues on myocardial dysfunction during reperfusion after ischemia in dogs. J Cardiovasc Pharmacol. 1996 Aug;28(2):264-70.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₁BrN₅O₇P

[ Molecular Weight ]:
424.10100

[ Exact Mass ]:
422.95800

[ PSA ]:
201.54000

[ LogP ]:
0.35710

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Recipient pretransplant inosine monophosphate dehydrogenase activity in nonmyeloablative hematopoietic cell transplantation.

Biol. Blood Marrow Transplant. 20(10) , 1544-52, (2014)

Mycophenolic acid, the active metabolite of mycophenolate mofetil (MMF), inhibits inosine monophosphate dehydrogenase (IMPDH) activity. IMPDH is the rate-limiting enzyme involved in de novo synthesis ...

Regulation of P450 oxidoreductase by gonadotropins in rat ovary and its effect on estrogen production.

Reprod. Biol. Endocrinol. 6 , 62, (2009)

P450 oxidoreductase (POR) catalyzes electron transfer to microsomal P450 enzymes. Its deficiency causes Antley-Bixler syndrome (ABS), and about half the patients with ABS have ambiguous genitalia and/...

Tonically Active cAMP-Dependent Signaling in the Ventrolateral Medulla Regulates Sympathetic and Cardiac Vagal Outflows.

J. Pharmacol. Exp. Ther. 356 , 424-33, (2016)

The ventrolateral medulla contains presympathetic and vagal preganglionic neurons that control vasomotor and cardiac vagal tone, respectively. G protein-coupled receptors influence the activity of the...

Related Compounds

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