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ACSS2-IN-2

Names

[ CAS No. ]:
2332820-04-7

[ Name ]:
ACSS2-IN-2

Biological Activity

[Description]:

ACSS2-IN-2 is an acyl-CoA synthetase short-chain family member 2 (ACSS2) inhibitor. ACSS2-IN-2 can inhibit ACSS2 activity with an IC50 value of 3.8 nM. ACSS2-IN-2 can be used for the research of several diseases, such as viral infection, metabolic disorders, neuropsychiatric diseases, inflammatory/autoimmune conditions and cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Infection
Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology
Research Areas >> Metabolic Disease
Research Areas >> Neurological Disease

[Target]

IC50: 3.8 nM (ACSS2)[1]


[In Vitro]

ACSS2-IN-2 (Compound 261) (5 h) has ACSS2 inhibitory activity with an IC50 value of 3.8 nM in MDA-MB-468 cells[1].

[References]

[1]. Philippe Nakache, et al. Acss2 inhibitors and methods of use thereof. Patent. WO2019097515A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H19F2N3O4

[ Molecular Weight ]:
415.4

Related Compounds