(2S)-2-Amino-4-pentynoic acid

Names

[ Name ]:
(2S)-2-Amino-4-pentynoic acid

[Synonym ]:
(S)-alpha-Propargylglycine
(S)-2-Aminopent-4-ynoic acid
(2S)-2-Amino-4-pentynoic acid
L-C-Propargylglycine
MFCD00077855
L-propargyl glycine
(2S)-2-aminopent-4-ynoic acid
4-Pentynoic acid, 2-amino-, (2S)-

Biological Activity

[Description]:

(S)-2-Aminopent-4-ynoic acid is a synthetic amino acid. (S)-2-Aminopent-4-ynoic acid can be used in synthesis of folate-conjugates and corresponding metal-chelate complexes[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Rudolf Moser, et al.Folate-conjugates and corresponding metal-chelate complexes for use in diagnostic imaging and radiotherapy. WO2008125618A1

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
272.1±35.0 °C at 760 mmHg

[ Melting Point ]:
232ºC

[ Molecular Formula ]:
C₅H₇NO₂

[ Molecular Weight ]:
113.115

[ Flash Point ]:
118.3±25.9 °C

[ Exact Mass ]:
113.047676

[ PSA ]:
63.32000

[ LogP ]:
-0.03

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.513

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2922499990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

[Hydrogen sulfide inhibits Ca(2+)-induced mitochondrial permeability transition pore opening in spontaneously hypertensive rats].

Fiziol. Zh. 59(1) , 3-10, (2013)

In experiments in vivo and in vitro on the mitochondria isolated from the control and spontaneously hypertensive rats (SHR) hearts, we studied the effects of a donor of hydrogen sulfide (H2S), NaHS, a...

Inhibition of cystathionine gamma-lyase and the biosynthesis of endogenous hydrogen sulphide ameliorates gentamicin-induced nephrotoxicity

Eur. J. Pharmacol. 685(1-3) , 165-73, (2012)

Clinical use of gentamicin over prolonged periods is limited because of dose- and time-dependent nephrotoxicity. Primarily, lysosomal phospholipidosis, intracellular oxidative stress and heightened in...

Interdependency of cystathione γ-lyase and cystathione β-synthase in hydrogen sulfide-induced blood pressure regulation in rats.

Am. J. Hypertens. 25 , 74-81, (2012)

Hydrogen sulfide (H(2)S), an endogenous vasoactive agent, is produced by cystathionine γ-lyase (CGL) and cystathionine β-synthase (CBS) enzymes. This study was conducted to evaluate the relative contr...