Mtb-IN-4

Names

[ Name ]:
Mtb-IN-4

Biological Activity

[Description]:

Mtb-IN-4 (compound 17h) is a nontoxic isoxazole, with anti-Mycobacterium tuberculosis (Mtb) activity (IC50=0.70 μM). Mtb-IN-4 inhibits Mtb respiration and biofilm formation in macrophage, and enhances antibiotic isoniazid (INH) inhibition against INH-resistant Mtb mutant[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

Mycobacterium tuberculosis (Mtb)[1]

[References]

[1]. Sarkar S, et al. Design, Synthesis, and Evaluation of Novel Δ2-Thiazolino 2-Pyridone Derivatives That Potentiate Isoniazid Activity in an Isoniazid-Resistant Mycobacterium tuberculosis Mutant. J Med Chem. 2023 Aug 24;66(16):11056-11077.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₁₈N₂O₄S

[ Molecular Weight ]:
430.48

Related Compounds

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