IM-250

Names

[ Name ]:
IM-250

Biological Activity

[Description]:

IM-250 is a potent HSV-1 helicase primase inhibitor, inhibits HSV-1 replication with IC50 of 20 nM (clinical isolate of HSV-1).IM-250 dispalys similar IC50 values (20-30 nM) against ACV-resistant HSV-1 clinical isolates 2 and 3 and ACV-resistant HSV-2 clinical isolates 7 and 8.IM-250 exhibits a broad therapeutic window against HSV-1 in vitro with pronounced higher SI values as obtained for acyclovir (ACV).IM-250 shows in vivo efficacy and attenuates viral burden in HSV-1 infection mouse model.

[References]

1. Uhlig N, et al. Antiviral Res. 2021 Nov;195:105190.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₉F₂N₃O₂S₂

[ Molecular Weight ]:
435.51

Related Compounds

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