IM-93

Names

[ Name ]:
IM-93

[Synonym ]:
3-{[3-(Dimethylamino)propyl]amino}-1-isopropyl-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 3-[[3-(dimethylamino)propyl]amino]-1-(1-methylethyl)-4-(1-methyl-1H-indol-3-yl)-
IM-93

Biological Activity

[Description]:

IM-93 inhibits ferroptosis and NETosis with an IC< sub>50 of 0.45 µM for cell death inhibition[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Apoptosis >> Ferroptosis

[References]

[1]. Dodo K, et al. Development of a Water-Soluble Indolylmaleimide Derivative IM-93 Showing Dual Inhibition of Ferroptosis and NETosis. ACS Med Chem Lett. 2019;10(9):1272-1278. Published 2019 Jul 30.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
540.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₈N₄O₂

[ Molecular Weight ]:
368.473

[ Flash Point ]:
280.5±30.1 °C

[ Exact Mass ]:
368.221222

[ LogP ]:
2.93

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.604

Related Compounds

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