IM-54

Names

[ Name ]:
IM-54

[Synonym ]:
IM-54
Necrosis Inhibitor,IM-54
1-Methyl-3-(1-methyl-1H-indol-3-yl)-4-(pentylamino)-1H-pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 1-methyl-3-(1-methyl-1H-indol-3-yl)-4-(pentylamino)-
IN1208

Biological Activity

[Description]:

IM-54 is a selective inhibitor of oxidative stress-induced necrosis. IM-54 shows potent inhibitory activity against H2O2-induced necrosis. IM-54 acts as a potential cardioprotective agent and biological tool for investigating the molecular mechanisms of cell death[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[In Vitro]

IM-54 selectively inhibits oxidative stress-induced necrosis, but it does not inhibit apoptosis induced by various anticancer drugs or Fas ligand, or necroptosis[1]. IM-54 shows strong inhibition of H2O2-induced necrosis, with an IC50 of 0.25 μM against HL-60 cells treated with H2O2[1].

[References]

[1]. Kosuke Dodo, et al. Indolylmaleimide Derivative IM-17 Shows Cardioprotective Effects in Ischemia-Reperfusion Injury. ACS Med Chem Lett. 2018 Mar 8; 9(3): 182–187.

[2]. Mikiko Sodeoka, et al. Development of selective inhibitors of necrosis. Chem Rec. 2010 Oct;10(5):308-14.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
511.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₃N₃O₂

[ Molecular Weight ]:
325.405

[ Flash Point ]:
263.1±30.1 °C

[ Exact Mass ]:
325.179016

[ PSA ]:
54.34000

[ LogP ]:
3.81

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.615

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ RIDADR ]:
UN 2811 6.1 / PGIII

Articles

Dynamin-related protein Drp1 and mitochondria are important for Shigella flexneri infection.

Int. J. Med. Microbiol. 304(5-6) , 530-41, (2014)

Shigella infection in epithelial cells induces cell death which is accompanied by mitochondrial dysfunction. In this study the role of the mitochondrial fission protein, Drp1 during Shigella infection...