Arachidonylcyclopropylamide

Names

[ Name ]:
Arachidonylcyclopropylamide

[Synonym ]:
N-cyclopropylicosa-5,8,11,14-tetraenamide
Arachidonylcyclopropylamide
(5Z,8Z,11Z,14Z)-N-Cyclopropylicosa-5,8,11,14-tetraenamide
5,8,11,14-Eicosatetraenamide, N-cyclopropyl-, (5Z,8Z,11Z,14Z)-
(5Z,8Z,11Z,14Z)-N-Cyclopropyl-5,8,11,14-icosatetraenamide

Biological Activity

[Description]:

Arachidonylcyclopropylamide (ACPA) is a potent and selective CB1 receptors agonist. Arachidonylcyclopropylamide inhibits forskolin-stimulated cAMP production in CHO cells transfected with human cannabinoid CB1 receptors (IC50=2 nM)[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor

[In Vitro]

Arachidonylcyclopropylamide induces a dose-dependent increase in BV-2 cell migration (EC50=2.2 nM)[2].

[References]

[1]. Franklin A, et al. Arachidonylcyclopropylamide increases microglial cell migration through cannabinoid CB2 and abnormal-cannabidiol-sensitive receptors. Eur J Pharmacol. 2003;474(2-3):195-198.

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
502.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₃₇NO

[ Molecular Weight ]:
343.546

[ Flash Point ]:
311.3±15.1 °C

[ Exact Mass ]:
343.287506

[ PSA ]:
29.10000

[ LogP ]:
6.61

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.513

Safety Information

[ WGK Germany ]:
3