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PI3K-IN-30

Names

[ CAS No. ]:
2281803-22-1

[ Name ]:
PI3K-IN-30

Biological Activity

[Description]:

PI3K-IN-30 (compound 6d) is a potent PI3K inhibitor with IC50s of 5.1, 136, 30.7 and 8.9 nM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

[Target]

PI3Kα:5.1 nM (IC50)

PI3Kβ:136 nM (IC50)

PI3Kγ:30.7 nM (IC50)

PI3Kδ:8.9 nM (IC50)


[References]

[1]. Van Dort ME, et al. Structural effects of morpholine replacement in ZSTK474 on Class I PI3K isoform inhibition: Development of novel MEK/PI3K bifunctional inhibitors. Eur J Med Chem. 2022;229:113996.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H25F2N7O3

[ Molecular Weight ]:
449.45

Related Compounds