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MK-0429

Names

[ CAS No. ]:
227963-15-7

[ Name ]:
MK-0429

[Synonym ]:
(3S)-3-(6-methoxypyridin-3-yl)-3-{2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]imidazolidin-1-yl}propanoic acid
1JL033A2D0
MK-0429
3-Pyridinepropanoic acid, 6-methoxy-β-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]-, (βS)-
(3S)-3-(6-Methoxy-3-pyridinyl)-3-{2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl}propanoic acid

Biological Activity

[Description]:

MK-0429 is a potent integrin antagonist with IC50s of 12.2 nM (α5β1 integrin) and 2.8 nM (αvβ3 integrin), respectively.

[Related Catalog]:

Signaling Pathways >> Cytoskeleton >> Integrin
Research Areas >> Inflammation/Immunology

[Target]

IC50: 12.2 nM (α5β1 integrin), 2.8 nM (αvβ3 integrin), 1.6 nM (αvβ1 integrin), 0.7 nM (αvβ6 integrin), 0.5 nM (αvβ8 integrin), 0.1 nM (αvβ5 integrin)[1].


[References]

[1]. Zhou X, et al. An integrin antagonist (MK-0429) decreases proteinuria and renal fibrosis in the ZSF1 rat diabetic nephropathy model.Pharmacol Res Perspect. 2017 Oct; 5 (5).


[Related Small Molecules]

Cilengitide | Cyclo(-Arg-Gly-Asp-D-Phe-Lys) trifluoroacetate salt | Arg-Gly-Asp-Ser | CWHM-12 | OSU-T315 | E 7820 | GLPG 0187 | Firategrast | ATN-161 trifluoroacetate salt | Cucurbitacin B | Eptifibatide acetate salt | iRGD peptide | Lifitegrast | Zaurategrast | Integrin Antagonist 1 (hydrochloride)

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
699.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H29N5O4

[ Molecular Weight ]:
439.508

[ Flash Point ]:
376.5±31.5 °C

[ Exact Mass ]:
439.221954

[ LogP ]:
2.90

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.606

Related Compounds