227963-15-7
227963-15-7 structure
- Name: MK-0429
- Chemical Name: MK-0429
- CAS Number: 227963-15-7
- Molecular Formula: C23H29N5O4
- Molecular Weight: 439.508
- Catalog: Signaling Pathways Cytoskeleton Integrin
- Create Date: 2018-06-12 16:27:04
- Modify Date: 2024-01-05 14:34:24
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MK-0429 is a potent integrin antagonist with IC50s of 12.2 nM (α5β1 integrin) and 2.8 nM (αvβ3 integrin), respectively.
| Name | MK-0429 |
|---|---|
| Synonyms |
(3S)-3-(6-methoxypyridin-3-yl)-3-{2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]imidazolidin-1-yl}propanoic acid
1JL033A2D0 MK-0429 3-Pyridinepropanoic acid, 6-methoxy-β-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]-, (βS)- (3S)-3-(6-Methoxy-3-pyridinyl)-3-{2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl}propanoic acid |
| Description | MK-0429 is a potent integrin antagonist with IC50s of 12.2 nM (α5β1 integrin) and 2.8 nM (αvβ3 integrin), respectively. |
|---|---|
| Related Catalog | |
| Target |
IC50: 12.2 nM (α5β1 integrin), 2.8 nM (αvβ3 integrin), 1.6 nM (αvβ1 integrin), 0.7 nM (αvβ6 integrin), 0.5 nM (αvβ8 integrin), 0.1 nM (αvβ5 integrin)[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 699.0±55.0 °C at 760 mmHg |
| Molecular Formula | C23H29N5O4 |
| Molecular Weight | 439.508 |
| Flash Point | 376.5±31.5 °C |
| Exact Mass | 439.221954 |
| LogP | 2.90 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.606 |