Pomalidomide 4'-PEG2-azide

Names

[ Name ]:
Pomalidomide 4'-PEG2-azide

Biological Activity

[Description]:

Pomalidomide 4'-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₂N₆O₆

[ Molecular Weight ]:
430.41

Safety Information

[ Hazard Codes ]:
Xi

Pomalidomide 4'-PEG2-azide

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds