Pomalidomide 4'-PEG3-azide

Names

[ Name ]:
Pomalidomide 4'-PEG3-azide

Biological Activity

[Description]:

Pomalidomide 4'-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a linker. Pomalidomide 4'-PEG3-azide can be used for the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3 is a highly efficient PARP1 degrader based on Rucaparib by using the PROTAC approach[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[Target]

Cereblon

[References]

[1]. Shuai Wang, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation. Nat Chem Biol. 2019 Dec;15(12):1223-1231.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₆N₆O₇

[ Molecular Weight ]:
474.47

[ Storage condition ]:
2-8°C

Related Compounds

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