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16,21-Epoxylanosta-7,24-diene-3,21-dione

Names

[ CAS No. ]:
22611-36-5

[ Name ]:
16,21-Epoxylanosta-7,24-diene-3,21-dione

[Synonym ]:
16,21-Epoxylanosta-7,24-diene-3,21-dione
Lanosta-7,24-diene-3,21-dione, 16,21-epoxy-

Biological Activity

[Description]:

Kulactone, a natural bioflavonoid and an inhibitor against jRdRp, possesses antifungal, antibacterial and antiplasmodial activities. Kulactone exhibit no crossing through Blood Brain Barrier (BBB)[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Fungal
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Rahab W Kamau, et al. Antimicrobial compounds from root, stem bark and seeds of Melia volkensii. Nat Prod Res. 2016 Sep;30(17):1984-7.

[2]. Vivek Dhar Dwivedi, et al. Mechanistic insights into the Japanese Encephalitis Virus RNA dependent RNA polymerase protein inhibition by bioflavonoids from Azadirachta indica. bioRxiv, 2021.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
562.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C30H44O3

[ Molecular Weight ]:
452.669

[ Flash Point ]:
236.9±30.2 °C

[ Exact Mass ]:
452.329041

[ PSA ]:
43.37000

[ LogP ]:
7.22

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.547

Related Compounds