USP15-IN-1

USP15-IN-1 is a potent USP15 inhibitor with an IC50 value of 3.76 μM. USP15-IN-1 can be used for researching anticancer[1].

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Deubiquitinase

IC50: 3.76 μM (USP15)[1]

USP15-IN-1 (compound IM001) (0.001-5 μM; 48 h) exhibits highly anti-proliferative activity against non-small cell lung carcinoma and leukemia cells[1]. Cell Proliferation Assay[1] Cell Line: Non-small cell lung carcinoma and leukemia cells Concentration: 0.001 μM, 0.005 μM, 0.01 μM, 0.05 μM, 0.1 μM, 0.5 μM, 1 and 5 μM Incubation Time: 48 h Result: Exhibited highly anti-proliferative activity against non-small cell lung carcinoma and leukemia cells with IC50s of 1.94 μM and 2.22 μM.

[1]. Chen Yihua, et al. The tetrahydro-beta-carboline micromolecular organic compound and its derivative and medical usage of a kind of hydroxyl substitution. CN108727370A