MB 0223

Names

[ Name ]:
MB 0223

Biological Activity

[Description]:

MB-0223 is a potent and selective dynamin-related GTPase Drp1 partial inhibitor (IC50=1.3 μM) over other dynamin family members, Opa 1 and dynamin-1 (IC50>100 μM)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cytoskeleton >> Dynamin

[Target]

IC50: 1.3 μM (Drp1)[1]

[In Vitro]

MB-0223 (30 μM; 48 hours) increases mitochondrial DNA levels in mfn1- knockout MEFs deficient in mitochondrial fusion[1]. MB-0223 (0-100 μM) is a partial inhibitor and exhibits a maximum inhibition of 67% of Drp1 activity. MB-0223 exhibits >100-fold selectivity for Drp1 over two other dynamin-like GTPases, Opa1 and Dnm1[1].

[References]

[1]. Ashley Mallat,et al. Characterization of Small Molecule Inhibitors of Drp1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₇N₅OS

[ Molecular Weight ]:
457.59

Related Compounds

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