MB-07344

Names

[ CAS No. ]:
852947-39-8

[ Name ]:
MB-07344

[Synonym ]:
unii-r1zw9h43zj

Biological Activity

[Description]:

MB-07344 is a thyroid hormone receptor (TR)-β agonist with a binding affinity Ki of 2.17 nM[1].

[Related Catalog]:

Signaling Pathways >> Others >> Thyroid Hormone Receptor

Research Areas >> Metabolic Disease

[Target]

Ki: 2.17 nM (Thyroid hormone receptor-β)[1]

[In Vivo]

MB-07344 (0.05 mg/kg; given i.v., 3 times per week for 3 weeks) results in adjunctive and additive activity when given in combination with atorvastatin in normal rabbits[1]. Animal Model: Normal rabbits[1] Dosage: 0.05 mg/kg Administration: Given i.v., 3 times per week for 3 weeks Result: Combination with atorvastatin further reduced cholesterol.

[References]

[1]. Ito BR, et al. Thyroid hormone beta receptor activation has additive cholesterol lowering activity in combination with atorvastatin in rabbits, dogs and monkeys. Br J Pharmacol. 2009 Feb;156(3):454-65.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₅O₅P

[ Molecular Weight ]:
364.37

[ Exact Mass ]:
364.14400

[ PSA ]:
96.80000

[ LogP ]:
4.23720

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.