2247732-89-2
2247732-89-2 structure
- Name: MB 0223
- Chemical Name: MB-0223
- CAS Number: 2247732-89-2
- Molecular Formula: C26H27N5OS
- Molecular Weight: 457.59
- Catalog: Signaling Pathways Cytoskeleton Dynamin
- Create Date: 2020-08-07 12:45:57
- Modify Date: 2024-01-16 12:24:02
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MB-0223 is a potent and selective dynamin-related GTPase Drp1 partial inhibitor (IC50=1.3 μM) over other dynamin family members, Opa 1 and dynamin-1 (IC50>100 μM)[1].
| Name | MB-0223 |
|---|
| Description | MB-0223 is a potent and selective dynamin-related GTPase Drp1 partial inhibitor (IC50=1.3 μM) over other dynamin family members, Opa 1 and dynamin-1 (IC50>100 μM)[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 1.3 μM (Drp1)[1] |
| In Vitro | MB-0223 (30 μM; 48 hours) increases mitochondrial DNA levels in mfn1- knockout MEFs deficient in mitochondrial fusion[1]. MB-0223 (0-100 μM) is a partial inhibitor and exhibits a maximum inhibition of 67% of Drp1 activity. MB-0223 exhibits >100-fold selectivity for Drp1 over two other dynamin-like GTPases, Opa1 and Dnm1[1]. |
| References |
[1]. Ashley Mallat,et al. Characterization of Small Molecule Inhibitors of Drp1. |
| Molecular Formula | C26H27N5OS |
|---|---|
| Molecular Weight | 457.59 |