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TUG-1375

Names

[ CAS No. ]:
2247372-59-2

[ Name ]:
TUG-1375

Biological Activity

[Description]:

TUG-1375 is an agonist of free fatty acid receptor 2 (FFA2/GPR43), with a pKi of 6.69. TUG-1375 is inactive on FFA3, FFA4, PPARα, PPARγ, PPARδ, LXRα or LXRβ[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[Target]

pKi: 6.69 (FFA2)[1]


[In Vitro]

TUG-1375 exhibits pEC50 of 7.11 in the cAMP FFA2 assay, also active on murine FFA2 orthologue (pEC50, 6.44 ± 0.13 in the cAMP assay)[1].

[References]

[1]. Hansen AH, et al. Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties. J Med Chem. 2018 Nov 8;61(21):9534-9550.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H19ClN2O4S

[ Molecular Weight ]:
442.92

[ Storage condition ]:
2-8℃

Related Compounds